You may want to revisit the idea of using 2W for the high ohms channel.<br>
When a measure function is associated with a channel, then when closing that channel, all the required channel pairing (in case of 4W) and backplane relays are managed for you.<br>
So a scan that uses both 2W and 4W will mange the backplanes appropriately for the closed channel.<br>
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If using a scan with mixed measure function type, I'm able to reliably measure 50MΩ (2Wire) and 0.5Ω (4Wire) on two different channels.  See attached.<br>
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If not performing a scan and attempting use of 4W with the 50MΩ, I find extra settling time is needed.<br>
I'm not able to find a command in the IVI driver.  So using the WriteString() to send:  ":ROUT:DEL 0.25, (@106)"  to obtain an extra 250msec on channel 106.<br>
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See attached for info on both defining a scan or the single channel read approach.